2025 will be a year of reckoning for Israeli Prime Minister Benjamin Netanyahu and his country's arch foe Iran.

The veteran Israeli leader is set to cement his strategic goals: tightening his military control over Gaza, thwarting Iran's nuclear ambitions and capitalising on the dismantling of Tehran's allies -- Palestinian Hamas, Lebanon's Hezbollah and the removal of Syrian president Bashar al-Assad.

Assad's collapse, the elimination of the top leaders of Hamas and Hezbollah and the destruction of their military structure mark a succession of monumental wins for Netanyahu.

Without Syria, the alliances Tehran has nurtured for decades have unraveled. As Iran's influence weakens, Israel is emerging as the dominant power in the region.

Netanyahu is poised to zero in on Iran's nuclear ambitions and missile program, applying an unyielding focus to dismantling and neutralising these strategic threats to Israel.

Iran, Middle East observers say, faces a stark choice: Either continue its nuclear enrichment program or scale back its atomic activities and agree to negotiations.

"Iran is very vulnerable to an Israeli attack, particularly against its nuclear program," said Joost R. Hiltermann, Middle East and North Africa Program Director of the International Crisis Group. "I wouldn't be surprised if Israel did it, but that doesn't get rid of Iran."

"If they (Iranians) do not back down, Trump and Netanyahu might strike, as nothing now prevents them," said Palestinian analyst Ghassan al-Khatib, referring to President-elect Donald Trump. Khatib argued that the Iranian leadership, having demonstrated pragmatism in the past, may be willing to compromise to avert a military confrontation.

Trump, who withdrew from a 2015 agreement between Iran and six world powers aimed at curbing Tehran's nuclear goals, is likely to step up sanctions on Iran's oil industry, despite calls to return to negotiations from critics who see diplomacy as a more effective long-term policy.